BIOMEDICINE: Anaerobic Bullets

Firing Agile Silver Bullets

With almost thirty years since the start of our quest to find Fred Brooks’ magical “Silver Bullet” to slay our productivity horrors, and twenty years since the first Standish report on IT project success and failures, are we getting closer? This paper discusses and challenges current thinking on process improvement initiates to provide answers of how we can significantly improve IT project prod...

Tropical Biomedicine

Biomedicine Select

Autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, are complex disorders characterized by an inflammatory response against the body's own tissues. Recent findings reveal new insights into how these diseases are initiated and progress and the factors that contribute to their clinical symptoms. Such work also pinpoints potential new therapeutic targets including the integra...

Biomedicine Select

This issue’s Biomedicine Select highlights new insights into the role of mitochondria in disease. Several new studies implicate abnormal mitochondria in the destruction of neurons of the substantia nigra, the cause of Parkinson’s disease (PD). Meanwhile, an elegant computational approach has enabled identification of candidate genes for several mitochondrial diseases including the mitochondrial...

Linear optical bullets

We describe a class of spatio-temporal optical pulses that spread neither spatially nor temporarily in linear dispersive media over long propagation distances. These new spatio-temporal pulses, referred to as linear optical bullets, can have any spatio-temporal profile and temporal width, and they carry a finite amount of energy. We also discuss in detail a technique for the experimental realiz...